Local Treatment of Trichomonas Vaginitis

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Abstract
According to Catterall and Williamson the treatment of trichomonas vaginitis is unsatisfactory. No medicament is effective systemically, and although some forms of local treatment are immediately effective the condition is prone to relapse. The assessment of any form of treatment is difficult because so many patients discontinue attendance and because there is no means of distinguishing between relapse and re-infection. The standard remedy, acetarsol, is an arsenical and its use occasionally results in sensitization which may be dangerous. It is desirable that an equally effective non-arsenical preparation should be available as an alternative. Clinical results obtained in the treatment of 215 cases of trichomonas vaginitis with acetarsol, Milibis (bismouth glycolylarsanilate), Aroxine (2-formamido-5-nitrothiazole), and some modifications are described. Milibis proved ineffective. Aroxine applied locally produced results which were comparable with, although possibly slightly inferior to, those obtained with acetarsol. Analogues of 2-formamido-5-nitrothiazole had no particular advantages.

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