Role of thyroid hormones in lipolysis

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Abstract
Epididymal fat from thyroidectomized and normal rats was incubated in the presence of various lipolytic agents, and free fatty acid (FFA) release, glycerol production, and glucose oxidation were measured. Thyroidectomy reduced but did not abolish the lipolytic effect of epinephrine. Propyl-thiouracil added to the diet had no effect in thyroidectomized animals. When the release of FFA and glycerol production was determined over a wide range of concentrations of epinephrine, the tissues of thyroidectomized animals were found capable of eliciting as great a response as normal, but approximately three times as much epinephrine was required. Over the same range of epinephrine concentrations thyroidectomy had no effect on the production of C14O2 from uniformly labeled glucose. Pretreatment with triiodothyronine increased the lipolytic response of adipose tissue to epinephrine but not the oxidation of glucose. The lipolytic effects of norepinephrine, isoproterenol, ACTH, [adreno-corticotropic hormone], TSH, [thyroid-stimulating hormone], and glucagon were similarly found to be sensitive to thyroid status.

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