A new type of safety-catch linker cleaved by intramolecular activation of an amide anchorage and allowing aqueous processing in solid-phase peptide synthesis
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1786-1788
- https://doi.org/10.1039/c39930001786
Abstract
The N3-phenyloxycarbonyl-L-2,3-diaminopropionic acid residue behaves as a versatile iinker [Dpr(Phoc)linker] displaying high stability under neutral and acidic conditions but undergoes activation under mild alkaline conditions for the release of peptide acids or amides by nucleophilic cleavage.Keywords
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