Acylthioxanthenes: agents which selectively reduce decerebrate rigidity in the cat
- 1 June 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (6) , 653-657
- https://doi.org/10.1021/jm00180a014
Abstract
A series of 2-acylthioxanthene-.DELTA.9(.gamma.)-propylamines was synthesized, and their effect of reducing the intercollicular decerebrate rigidity in the cat was evaluated. The compound exhibiting the greatest separation between the dosage that reduced rigidity and that which caused sedation was (Z)-2-propionyl-9-[3-(dimethylamino)propylidene]thioxanthene. The separation of Z and E isomers was monitored by 1H NMR spectroscopy, using a europium shift reagent.This publication has 0 references indexed in Scilit: