EVIDENCE FOR THE ACTIVATION OF THE KALLIKREIN-KININ SYSTEM IN EXPERIMENTAL ASBESTOSIS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (1) , 93-98
Abstract
Immunoreactive bradykinin (BK) and its metabolites, i.e., des-Arg9-BK and des(Phe8,Arg9)-BK, were measured in acidic extracts of lungs from normal and asbestos-treated guinea pigs. The development of experimental asbestosis did not change the levels of BK (0.67 ng/mg and 0.72 ng/mg) while the levels of des-Arg9-BK increased from 0.06 to 0.57 ng/mg (P < 0.01) and those of des(Phe8, Arg9)-BK, from 0.09 to 1.48 ng/mg (P < 0.01). These increases in the amount of the BK metabolites suggest the participation of the kallikrein-kinin system in the inflammatory reaction induced by the intratracheal administration of asbestos into guinea pigs.

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