DOPAMINE INHIBITS32PiINCORPORATION INTO PHOSPHATIDYLINOSITOL IN THE ANTERIOR PITUITARY GLAND OF THE RAT
- 1 July 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 111 (1) , 347-349
- https://doi.org/10.1210/endo-111-1-347
Abstract
The hi vitro effect of dopamine, haloperidol and pimozide on 32pi incorporation into phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by anterior pituitary glands was studied. Dopamine decreased the incorporation of 32pi into phosphatidylinositol in a dose-related manner without affecting phosphatidyicholine and phosphatidylethanolamine. Haloperidol and pimozide did not modify 32pi incorporation into these phospholipids by themselves but completely reversed the inhibitory effect of dopamine on phosphatidylinositol. The inhibition of 32pi incorporation into phosphatidyiinositol synthesis in the presence of 500 nM dopamine was significant at 20 min of incubation and maximal at 30 min. The possibility that a decrease in phosphatidylinositol cleavage and turnover may be involved in the inhibitory regulation of prolactin secretion by DA is suggested.Keywords
This publication has 13 references indexed in Scilit:
- PITUITARY CYCLIC-NUCLEOTIDES AND THYROTROPIN-RELEASING-HORMONE ACTION - THE RELATIONSHIP OF ADENOSINE-3',5'-MONOPHOSPHATE AND GUANOSINE 3',5'-MONOPHOSPHATE TO THE RELEASE OF THYROTROPIN AND PROLACTIN1980
- Calcium Rather Than Cyclic AMP as the Physiological Intracellular Regulator of Prolactin ReleaseNeuroendocrinology, 1980
- ACETYLCHOLINE STIMULATES GROWTH HORMONE SECRETION, PHOSPHATIDYL INOSITOL LABELLING, 45Ca2+ EFFLUX AND CYCLIC GMP ACCUMULATION IN BOVINE ANTERIOR PITUITARY GLANDSJournal of Endocrinology, 1979
- Effect of TRH and dopamine on cyclic AMP levels in enriched mammotroph and thyrotroph cellsMolecular and Cellular Endocrinology, 1978
- The Biphasic Regulation of Prolactin Secretion by Dopamine Agonist-Antagonists*Endocrinology, 1978
- Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.Journal of Biological Chemistry, 1978
- Binding of Dopamine to Bovine Anterior Pituitary Gland MembranesNeuroendocrinology, 1978
- Action potentials occur in cells of the normal anterior pituitary gland and are stimulated by the hypophysiotropic peptide thyrotropin-releasing hormone.Proceedings of the National Academy of Sciences, 1977
- The Rapid Incorporation of Phosphate into Mitochondrial LipidsJournal of Biological Chemistry, 1963
- Phospholipides and the Secretion of Adrenocorticotropin and of CorticosteroidsJournal of Biological Chemistry, 1958