SHOE-DYE POISONING—RELATION TO METHEMOGLOBIN FORMATION

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Abstract
The first cases of shoe-dye poisoning following the wearing of recently dyed shoes were reported in 1900.1Following this, Stone2reported a fatal case with necropsy observations in a young man. Numerous cases have appeared since in the literature. Although black shoe dye was responsible in most instances, Stifel,3in 1919, reported seventeen cases originating in an army camp in which brown dye had been used. Subsequently Muehlberger,4analyzing the forty-eight cases reported up to then in the American and European literature, found that in the twenty-five American cases nitrobenzene was the toxic agent. He found that aniline was the chief toxic agent in the European cases reported. In the ten cases which he reported at that time, Muehlberger found that six were due to aniline, these being the first to be reported in this country. Pateh5has recently reported three more cases due to

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