Human Cytomegalovirus DNA Is Present in CD45+ Cells in Semen from Human Immunodeficiency Virus-Infected Patients
- 1 February 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 171 (2) , 432-436
- https://doi.org/10.1093/infdis/171.2.432
Abstract
Human cytomegalovirus (CMV) DNA was detected and quantitated in both blood and semen cells from human immunodeficiency virus (HIV)-infected men with 100–800 CD4 cell counts/mm3 . None of the 35 patients studied had demonstrable CMV DNA in mononuclear cells isolated from blood. Blood samples from 8 of these patients were cultured for CMV and found to be negative. About 30% of HIV-seropositive patients in the study group had > 100 copies of CMV in emen (range, > 100 to > 106 ; mean, ∼100,000). Persistent CMV infection was detected for > 8 months in some patients with no obvious signs or symptoms of CMV disease. The CMV-infected cell in semen was CD45+ and probably had Fe receptors. Mature spermatozoa were not a major reservoir of CMV infection.Keywords
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