Experimental Coronary Arteriography

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Abstract
The nature and incidence of the injuries occurring in various methods of coronary arteriography have been tabulated in 60 dogs subjected to supravalvular angiography, and in 30 subjected to selective coronary catheterization. Supravalvular coronary arteriography was considered a relatively benign procedure since only 4 of the 60 animals (7%) displayed lesions at autopsy which could be attributed to either the injection of the contrast medium, the required catheter manipulations, or both of these factors. In marked contrast, a high incidence of lesions occurred in the animals subjected to selective coronary catheterization. Extensive hemorrhage of the valve leaflet adjacent to the catheterized coronary artery was found in 8 of the 30 animals (27%), while 42% of these dogs also showed aortic wall lesions consisting of intimal fibrosis with adherent thrombi. These lesions were usually located on the greater curvature aspect of the aortic arch where the catheter banks against the aortic wall. Selective coronary arteriography, therefore, may not be as benign as once supposed. Further experimentation is needed to determine the inherent factors in arteriographic techniques responsible for producing these lesions.

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