Formation of Through-Ring α-Cyclodextrin Complexes with α,ω-Alkanedicarboxylate Anion.Effects of the Aliphatic Chain Length and Electrostatic Factors on the Complexation Behavior
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 65 (1) , 164-169
- https://doi.org/10.1246/bcsj.65.164
Abstract
α,ω-Alkanedicarboxylic acid anions with a long spacer methylene chain were observed to form dynamically and statically stable complexes with α-cyclodextrin (α-CD) at an NMR time scale in both neutral and basic media. The structures of these complexes were confirmed to be a “through-ring” type CD complex by measurements of the intermolecular NOESY and NOE difference spectra. From the thermodynamic data in basic media (pD 13), the dynamical stability of these type complexes were attributed not to the steric interaction, but to an electrostatic interaction between the dicarboxylate anion and ionized-CD.Keywords
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