Predictive Value of Uterine Contractility and the Serum Levels of Progesterone and Oestrogens with Regard to Preterm Labour

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Abstract
A longitudinal investigation regarding the serum concentrations of estradiol, estriol and progesterone in relation to uterine activity was performed in 80 healthy primigravid women during the course of pregnancy up to the 37th week of pregnancy. The frequency of uterine contractions was quantitatively objectivated by means of external tocodynamometry; simultaneously the uterine activity was recorded by the pregnant women qualitatively. There apparently is a gradual increase of all the 3-mentioned hormones during the course of pregnancy. There is a large interindividual spread. There exists no relation between the hormonal serum levels and uterine activity (quantitatively as well as qualitatively recorded). Between these 2 latter there is a poor relation. It is impossible to predict the occurrence of preterm birth based on hormonal serum changes. This holds for the progesterone-estradiol ratio.

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