Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
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- 10 April 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (5) , 594-596
- https://doi.org/10.1038/nn1438
Abstract
Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.Keywords
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