A Ubiquitous Tissue Antigen and its Corresponding Antibody in Sera of Patients with Glomerulonephritides

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Abstract
Sera and 5% PEG[polyethylene glycol]-precipitates from 20 patients with IMN [idiopathic membranous nephropathy], 18 with MPGN [membranoproliferative glomerulonephritis], 20 with SLE [systemic lupus erythematosus], 8 with anti-GBM [glomerular basement membrane] disease and 17 with other varieties of glomerulonephritides, 19 patients with chronic liver or intestinal diseases, as well as those from 40 healthy adults, were tested by gel precipitation for the presence of a ubiquitous tissue antigen (UTA) and/or its corresponding antibody (previously shown to be associated with renal disorders). The antigen was detected in sera of 5 patients with IMN, 1 with anti-GBM disease and 1 with SLE. Corresponding antibodies were present in sera of 2 patients with IMN. In 4 of 5 patients with IMN, the UTA was only detected if the sera were first treated with PEG (MW 6000) which induces precipitation of antigen-antibody complexes and other high molecular weight components in serum. The UTA was not detected in renal glomeruli by immunofluorescence. The possible significance of these findings in the pathogenesis of renal diseases is discussed.

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