A CONFORMATIONAL ANALYSIS FOR LEUCINE‐ENKEPHALIN USING ACTIVITY AND BINDING DATA OF SYNTHETIC ANALOGUES
Open Access
- 1 November 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 61 (3) , 351-356
- https://doi.org/10.1111/j.1476-5381.1977.tb08427.x
Abstract
1 Leucine-enkephalin and some analogues were assayed for activity in vitro on the mouse vas deferens and for binding to opiate receptors from rat brain. 2 The experimental data were analysed in terms of the stringency for glycine, a D-amino acid or an L-amino acid at each position in the peptide. 3 The observed configurational specificity was compared with the stringency that would be predicted to occur if enkephalin adopted certain hydrogen-bonded conformations at the receptor. 4 A small subset of the conformations examined was found to be compatible with the experimental data.Keywords
This publication has 22 references indexed in Scilit:
- Structural requirements for opioid activity of analogues of the enkephalinsProceedings of the Royal Society of London. B. Biological Sciences, 1977
- An explanation for the rare occurrence of cis peptide units in proteins and polypeptidesJournal of Molecular Biology, 1976
- Biosynthetic origin and receptor conformation of methionine enkephalinNature, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Some thoughts on the significance of enkephalin, the endogenous ligandLife Sciences, 1975
- Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antatonist propertiesBiochemistry, 1973
- The γ Turn, a Possible Folded Conformation of the Polypeptide Chain. Comparison with the β TurnMacromolecules, 1972
- Stereochemistry of polypeptide chain configurationsJournal of Molecular Biology, 1963
- Fundamental dimensions of polypeptide chainsProceedings of the Royal Society of London. B. Biological Sciences, 1953