Thymidine Kinase in IDU Resistance.

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Abstract
Summary Studies were done to determine whether 5-iodo-2′-deoxyuridine resistance of herpes simplex in rabbit corneal infection was a function of thymidine kinase deficiency in the viral genome. Herpes simplex virus passed in rabbit kidney cells in the presence of 5-iodo-2′-deoxyuridine was resistant to it in vivo although this resistant virus induced normal amounts of thymidine kinase in mutant LM cells deficient in thymidine kinase. A different strain deficient in thymidine kinase was susceptible to 5-iodo-2′-deoxy-uridine in vivo, presumably because 5-iodo-2′-deoxy uridine was phosphorylated by cellular thymidine kinase. Viral resistance to 5-iodo-2′-deoxyuridine, unlike the resistance of cancer cells, cannot depend solely on the loss of thymidine kinase inducing ability.

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