The immunological response of the rat to infection with Taenia taeniaeformis. I. Immunoglobulin classes involved in passive transfer of resistance.

  • 1 August 1974
    • journal article
    • Vol. 27  (2) , 195-208
Abstract
Passive transfer of immunity to Taenia taeniaeformis infection in the rat was achieved with serum taken 14, 21 and 28 days after infection, with maximal activity at 28 days. The protective capacity resided in the globulin fraction, which was further fractionated by gel filtration and anion exchange chromatography. The immunoglobulins present in each passively transferred fraction were detected with specific antisera to 7Sγ2, 7Sγ1, γM and γA. Protective activity was confined to those fractions containing 7S immunoglobulin. Fractions enriched for γM were unable to confer protection and it was possible to protect recipient rats against challenge with fractions devoid of γA and reaginic antibody activity. 7Sγ2a antibodies were able to confer passive protection when given alone, and probably contributed to the protective capacity of mixtures containing 7Sγ2 and 7Sγ1 immunoglobulins. A mechanism for specific acquired resistance to T. taeniaeformis is proposed based upon the recently established biological properties of 7Sγ2a.