Organ specific expression of ras oncoproteins during growth and development of the rat
- 1 April 1986
- journal article
- research article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 70 (1) , 97-104
- https://doi.org/10.1007/bf00233807
Abstract
Expression of proteins encoded by the ras proto-oncogenes was examined in extracts from normal rat organs using anti-ras p21 antibodies generated against synthetic peptides. The highest level of ras p21 was found in brain (cerebrum) and was predominantly of c-Ha-ras origin. Levels of brain ras p21 did not vary from the newborn period of 3 months of age. Moderate levels of ras p21s were detected in lung, spleen and thymus. In contrast to the p21 in brain, these levels varied with the age of the rats and were encoded by other members of ras proto-oncogene family (Ki-ras or N-ras). This organ specific expression of different ras genes might be related to developmental control of gene expressions.Keywords
This publication has 37 references indexed in Scilit:
- Effect of divalent metal ions and glycerol on the GTPase activity of H-ras proteinsBiochemical and Biophysical Research Communications, 1985
- Primary structure of the α-subunit of transducin and its relationship to ras proteinsNature, 1985
- Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation FactorsScience, 1985
- Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viabilityNature, 1984
- G proteins and dual control of adenylate cyclaseCell, 1984
- Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteinsCell, 1984
- Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologueNature, 1983
- A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogeneNature, 1982
- The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipidPublished by Elsevier ,1982
- Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistryCell, 1980