An Unusual Cluster of Cases of Castleman's Disease during Highly Active Antiretroviral Therapy for AIDS

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Abstract
Castleman and coworkers first described a lymphatic hyperplasia now called Castleman's disease, which has two forms, the hyaline vascular type (found in 90 percent of cases) and the plasma-cell type (found in 10 percent).1,2 Patients may present with a multicentric lymphadenopathy and progressive systemic symptoms or with a more localized, indolent disease that can often be cured by local excision. The majority of patients with so-called multicentric Castleman's disease have the plasma-cell–rich variant with an interfollicular predominance of plasma cells on histologic analysis.2,3 Multicentric Castleman's disease is associated with infection with human herpesvirus 8 (HHV-8)4,5 and is occasionally found with Kaposi's sarcoma.3-5