Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene
Open Access
- 1 January 1994
- journal article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 1994 (Supplement) , 63-68
- https://doi.org/10.1242/jcs.1994.supplement_18.9
Abstract
We have identified the rum1+ gene as a new regulator of the G1-phase of the fission yeast cell cycle. rum1+ determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1+ are unable to arrest in pre-Start G1 in response to nitrogen starvation and are subsequently sterile. In addition, rum1+ prevents entry into mitosis from pre-Start G1, as shown by the fact that cdc10 mutants in the absence of rum1+ undergo lethal mitosis without entering S-phase.Keywords
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