Radio-iodobenzylguanidine scintigraphy of neuroblastoma: Conflicting results, when compared with standard investigations

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Abstract
Seventy‐one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow‐up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x‐ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA‐excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor‐suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy.