A Promising Cyclization of the 3-Arylidene-6-arylmethyl-2,5-piperazinedione to Construct Tricyclic Lactam as an Intermediate to Saframycin Synthesis
- 1 January 1987
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 26 (7) , 1765-1770
- https://doi.org/10.3987/r-1987-07-1765
Abstract
Regioselective reduction of the 3-arylidene-6-aryl-methyl-2, 5-piperazinedione (7b) at the C-2 position, followed by effective intramolecular cyclization to afford the tricyclic lactam (10b) is described. The structure of 16 as an intermediate to saframycin synthesis is confirmed by an X-ray crystallographic analysis.Keywords
This publication has 2 references indexed in Scilit:
- Structure of saframycin D, a new dimeric isoquinolinequinone antibiotic.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Biosynthetic studies on saframycin A, a quinone antitumor antibiotic produced by Streptomyces lavendulae.Journal of Biological Chemistry, 1985