Uretnia Decreases Nuclear 3,5,3′-Triiodothyronine Receptors in Rats*

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Abstract
The maximal binding capacity (MBC) of hepatic T3nuclear receptors was decreased in uremic rats (132 ± 37 fmol/mg DNA) compared to sham-operated controls (212 ± 44 fmol/mg DNA; Pa) remained unaltered (1.8 ± 0.4 and 1.5 ± 0.3 × 109l M-1 in the uremic and control rats, respectively, P = NS). There was also a reduction in the MBC of the kidney T3 receptors, from 73 ± 14 fmol/mg DNA in the control animals to 32 ± 7 fmol/mg DNA in the uremic rats (Pa values were identical in both groups (1.9 ± 0.5 × 109) M-1). In addition, there were significant reductions in serum T4 (1.5 ± 0.7 μ/dl) and T3 (92 ± 10 ng/dl) in the uremic rats compared to control rats, whose T4 levels averaged 4.4 ±0.1 μg/dl (P3 levels averaged 140 ± 13 ng/dl (P3 receptors, 2) the reduction in MBC observed may be generalized rather than organ specific for hepatic nuclear receptors, and 3) elevated glucagon levels are associated with reduced MBC in uremia, but it is indeterminate whether hyperglucagonemia is the etiology of the decrease.