Endocrine Influences on Ulceration and Regeneration in the Alkali-Burned Cornea
- 1 October 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 95 (10) , 1866-1870
- https://doi.org/10.1001/archopht.1977.04450100168024
Abstract
• Subconjunctival dibutyryl 3′,5′ cyclic adenosine monophosphoric acid (DBcAMP) produced a statistically significant reduction of ulceration in the alkaliburned rabbit cornea. No effect on epithelial cell growth was observed. DBcAMP also caused a statistically significant acceleration of corneal neovascularization in the first two weeks postburn. Medroxyprogesterone acetate also affected the development of corneal ulcers postalkali burn, but in a less well-defined manner. Dinoprost and indomethacin did not seem to influence this lesion. Cyclic adenosine monophosphoric acid may therefore possess a potential for use in the alkali-burned human eye. (Arch Ophthalmol 95:1866-1870, 1977)This publication has 21 references indexed in Scilit:
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