Effect of Jejunoileal Bypass Operation and Billroth II Resection on Postprandial Plasma Pancreatic Polypeptide Release

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Abstract
In 5 jejunoileal bypass-operated subjects mean plasma pancreatic polypeptide (PP) values were significantly higher 15, 30 and 60 min after start of a meal 2 wk postoperatively and 15 min after start of a meal 6 wk postoperatively, as compared with preoperative values. In a group of 8 obese subjects, operated on with jejunoileal bypass 2-5 yr ago, the postprandial plasma PP release tended to be higher than in an age-matched control group, the difference, however, being significant at 15 min only. The postprandial plasma PP release in a group of 6 Billroth-II-resected patients was almost identical to that seen in an age-matched control group. Apparently neither the antrum nor the small intestine is a prerequisite for a normal PP response to a mixed liquid test meal.