Selective alteration of neurotransmitter release by low oxygen in vitro
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 9 (8) , 1039-1049
- https://doi.org/10.1007/bf00964800
Abstract
The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603±6 to 22±2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but did not change their calcium-independent release. The calcium-dependent release of [14C]acetylcholine decreased (39%), while that of glutamate increased (66%) and 4-aminobutyrate, [3H]norepinephrine, and [3H]serotonin were unaffected. Thus, low oxygen reveals variations in the calcium-dependent release mechanisms of several neurotransmitters. These differences may have important implications for pharmacological intervention of neurotransmitter release.Keywords
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