THE ACTION OF PROPIONYL ATROPINE METHYL NITRATE ON GASTRIC FUNCTION

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Abstract
A quaternary compound, propionyl atropine methyl nitrate, previously demonstrated to have muscarinic and ganglionic blocking properties has been shown to decrease the volume and acidity of the gastric juice in man. Using a variation of the glucose tolerance test the compound was also shown to reduce the motility of the alimentary tract. Side effects due to parasympathetic blockade were in most cases absent at the doses used. A clinical trial with 26 cases of peptic ulcer has resulted in a complete alleviation of symptoms without the production of side actions. In six cases the trial has extended for six months without the development of tolerance.

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