Synthesis of oligonucleotides containing 5-(hydroxymethyl)-2'-deoxyuridine at defined sites
- 1 March 1993
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 58 (7) , 1664-1665
- https://doi.org/10.1021/jo00059a011
Abstract
A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2'-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.Keywords
This publication has 13 references indexed in Scilit:
- Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivoAnalytical Biochemistry, 1991
- Modification of DNA bases in mammalian chromatin by radiation-generated free radicalsBiochemistry, 1990
- Genetic effects of 5-hydroxymethyl-2′-deoxyuridine, a product of ionizing radiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1987
- Radiation-induced DNA Damage and Its RepairInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1987
- In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2′ deoxyuridineBiochemical Pharmacology, 1986
- Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2′-deoxyuridine analogs in the Ames Salmonella/microsome testMutation Research/Genetic Toxicology, 1986
- Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repairCarcinogenesis: Integrative Cancer Research, 1986
- Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of .gamma.-irradiated cellsBiochemistry, 1985
- Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.Proceedings of the National Academy of Sciences, 1984
- Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogsJournal of Medicinal Chemistry, 1980