Susceptibility of Pseudomonas pseudomallei to new β-lactam and aminoglycoside antibiotics

Abstract
Pseudomonas pseudomallei is resistant to many antimicrobial agents. We determined the susceptibility to twelve β-lactams and six aminoglycosides of twelve isolates of P. pseudomallei. Imipenem (MIC range 0·5-1·0 mg/l; MIC90 10 mg/l), ceftazidime (MIC range 1–8 mg/l; MIC90 8·0 mg/l), amoxycillin/clavulanate (MIC range 4–8 mg/l; MIC90 8·0 mg/l), piperacillin (MIC range 4–16 mg/l; MIC90 8·0 mg/l), and carumonam (MIC range 4–;16 mg/l; MIC90 8·0 mg/l) were the most active. Aminoglycosides were relatively inactive, for example, gentamicin (MIC range 16–64 mg/l; MIC90 64 mg/l), netilmicin (MIC range 16–128 mg/l; MIC90 128 mg/l) and amikacin (MIC range 32–64 mg/l; MIC90 64 mg/l).