Histamine receptors in the bronchial musculature and vasculature of the dog.

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Abstract
Participation of histamine H1 and H2-receptors in the bronchial musculature and vasculature of the dog was investigated by evaluating airway responses. A peristaltic pump and a Starling pneumatic resistance were used for constant pressure perfusion. Dogs given 0.1-10 .mu.g histamine by a close i.a. [intra-arterial] injection showed increases in ventilation overflow (bronchoconstriction) and in blood flow (bronchial vasodilatation) in a dose-dependent manner. The bronchoconstriction produced by histamine was antagonized strongly by chlorpheniramine, a H1-receptor antagonist, but not modified by cimetidine, a H2-receptor antagonist. The bronchial vasodilatation produced by histamine was antagonized by both chlorpheniramine and cimetidine. Histamine evokes bronchoconstriction through H1-receptors and bronchial vasodilatation through H1- and H2-receptors.

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