Isolation and characterization of a new thio-glucuronide, a biliary metabolite of malotilate in rats
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 19 (2) , 209-216
- https://doi.org/10.3109/00498258909034693
Abstract
1. The metabolism of malotilate, possessing a 1,3-dithiole ring, was studied in rats. A major biliary metabolite of malotilate was isolated and determined to be a thio-glucuronide of the dithiol formed by ring-opening, namely, 1-mercapto-2,2-di(isopropoxycarbonyl)-ethenyl 1-thio-β-D-glucosiduronic acid. The structure was elucidated by proton-n.m.r., 13C-n.m.r. and high-resolution mass spectrometry. 2. The thio-glucuronide was completely hydrolysed by β-glucuronidase. This enzymic reaction was inhibited by saccharo-1,4-lactone.This publication has 7 references indexed in Scilit:
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