Respiratory System

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10.1 Upper respiratory tract disease and bronchial asthma 2006357 Observation of airway hyperresponsiveness and inflammatory markers in induced sputum in elderly patients with stable late onset asthma during the remission period. NIE Han-xiang, et al. Dept Respir Dis, Renmin Hosp, Wuhan Univ, Wuhan 430060. Chin J Geriatr 2006;25(5):328-331. Objective:To investigate the clinical significance of airway hyperresponsiveness, eosinophil (Eos) percentage, levels of eosinophil cationic protein (ECP) and interleukin-5 (IL-5) in induced sputum in elderly patients with late onset asthma (LOA)during the remission period. Methods: Fifty-eight elderly patients with LOA during the remission period were selected. Bronchial challenge test was performed and the percentage of Eos and levels of ECP and IL-5 in induced sputum were measured by Wrights′ stain, immuno-CAP system and ELISA, respectively. Twenty-five elderly patients with LOA during their exacerbation period and 15 healthy elderly subjects were selected as control. Results:In fifty-eight LOA patients during their remission period, 49 cases (84.5%) showed positive bronchial challenge test and 9 cases(15.5 %) negative. The percentage of Eos, levels of ECP and IL-5[(9.3± 3.1)%], [(144.2±68.1) μg/L] and [(20.3±6.3) μg/L], in induced sputum in patients with LOA during their remission period were lower than those[ (21.1±9.8)%, (399.3±172.5) μg/L] and[(50.6±10.7) μg/L, respectively]in LOA group during the exacerbation period, and higher than those[(1.3±0.7)%,(48. 7±21.9) μg/L and (10.3±3.2) μg/L]in healthy group(all P<0.01). The percentage of Eos, levels of ECP and IL-5 in induced sputum were all higher [(12.7±3.6)% ]vs [(3.1±1. 3)%], [(171.3±69.8) μg/L] vs [(52.7±21.1) μg/L] and [(23.6±8.5) μg/L]vs[(13.7±4.1) μg/L] (all P<0.01) in positive group than negative group of bronchial challenge test in LOA patients during remission period.

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