Human Leukocyte Antigen Class I and II Alleles and Response to Interferon?? Treatment, in Taiwanese Patients with Chronic Hepatitis C Virus Infection
Open Access
- 1 July 2003
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 188 (1) , 62-65
- https://doi.org/10.1086/375554
Abstract
To investigate the influence of immunogenetics on response to interferon (IFN)-α treatment, human leukocyte antigen alleles were characterized in 100 unrelated Taiwanese patients with chronic hepatitis C virus (HCV) infection. A11, B51, Cw15, and DRB1*15 were positively correlated with sustained response, whereas A24 was inversely associated with response to IFN-α, after adjustment for cirrhosis, pretreatment virus load, and viral genotype. Homozygote-genotype analysis showed that A24 and DQB1*05 probably had gene-dosage effect on sustained response. DRB1*15 was in strong linkage disequilibrium with DQB1*05 and DQB1*06, but only haplotype DRB1*15-DQB1*05 was associated with response to IFN-α. Haplotype A11-DRB1*15 was strongly associated with sustained response. This suggests a role for a complex hostimmunogenetics interplay in the response to IFN-α, in patients with chronic HCV infection.Keywords
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