Release by ethanol of vitamins into rat liver perfusates

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Abstract
In vitro perfusion of rat liver with ethanol (EtOH) causes a release of all vitamins from the liver stores, except biotin, vitamins A, E, C, and β-carotene. The concentration of vitamins released from the liver by EtOH in decreasing order was B12 > B6 > pantothenate > thiamin > riboflavin > nicotinate > folate. The B12 concentration in the EtOH perfusate was high when compared with the perfusate without EtOH, implying that B12 can be rapidly released from a liver exposed to EtOH. Results also suggest that when a liver exposed to EtOH releases a vitamin from its stores, it cannot rebind the released vitamin while EtOH is being recirculated.