ENANTIOFACE DIFFERENTIATING (ASYMMETRIC) HYDROGENATION OF METHYL ACETOACETATE WITH MODIFIED RANEY NICKEL
- 5 August 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 3 (8) , 935-938
- https://doi.org/10.1246/cl.1974.935
Abstract
Rate studies of the liquid phase hydrogenation of methyl acetoacetate were carried out on the Raney nickel catalyst modified with optically active substances. The results are as follows ; 1) Both the optical yield of product and the rate of hydrogenation were controlled by the nature of modifying reagents but no direct correlation was present between them. 2) The apparent activation energy of hydrogenation was not varied with the change of modifying reagents. The most probable rate-controlling process of hydrogenation was the surface reaction. The optical yield of product was not explained by the simple kinetic controlled differentiation. Details of differentiating process still remained equivocal.Keywords
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