Acute Dystonic Reaction in Normal Humans Caused by Catecholamine Depletion
- 1 December 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Clinical Neuropharmacology
- Vol. 13 (6) , 565-568
- https://doi.org/10.1097/00002826-199012000-00009
Abstract
Summary Five of 24 (21%) normal men (volunteers) administered α-meth-yl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neu-rotransmitter imbalances may lead to idiopathic primary dystonia.Keywords
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