Respiratory dynamic resistance

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Abstract
Sinusoidal forcing at frequencies up to 17 cycles/sec was applied to the anesthetized, apneic dog by a body respirator. Forcing pressure and volume displacement were displayed in quadrature on an oscilloscope and planimetric integration of these loops indicated an increase in energy dissipated by total respiratory resistance per liter of air displaced, due to turbulence and changing airway geometry, with increasing frequency. Nonlinear resistance was calculated and the differential coefficient, dP/dV (dynamic resistance), was determined at 10° intervals throughout the respiratory cycle, at each of three frequencies in four dogs. Total respiratory resistance is a “nonohmic” dependent variable and changes progressively throughout the cycle. Submitted on October 20, 1961

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