Anti‐Idiotypic B‐Cell Lines from a Patient with Monoclonal Gammopathy of Undetermined Significance
- 1 October 1989
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 30 (4) , 489-492
- https://doi.org/10.1111/j.1365-3083.1989.tb02454.x
Abstract
The B-cell repertoire in a patient with benign monoclonal gammopathy of unknown significance was studied using Epstein-Barr virus transformation of peripheral lymphocytes. The presence of anti-idiotypic B cells producing monoclonal antibodies that reacted with idiotypic determinants on the monoclonal immunoglobulin was verified. The two monoclonal anti-idiotypic antibodies studied were of the IgM-K type. Such anti-idiotypic antibodies may be part of an idiotypic network regulation of the monoclonal B-cell population.This publication has 9 references indexed in Scilit:
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