Cyclic metabolic pathway of a butylated hydroxytoluene by rat liver microsomal fractions
- 1 December 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 144 (3) , 497-501
- https://doi.org/10.1042/bj1440497
Abstract
A cyclic metabolic pathway was obtained when 3,5-di-t-butyl-4-hydroxytoluene (BHT) was incubated with a rat liver microsomal preparation. The pathway is as follows: BHT → 4-hydroperoxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-OOH) → 4-hydroxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-30OH) → BHT. This metabolic pathway suggests that antioxidants such as BHT owe their high efficacy, at least in part, to their metabolic regeneration.Keywords
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