Hormone Resistance and Hormone Sensitivity

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Abstract
ON casual inspection the study by Oseid et al., "Decreased Binding of Insulin to Its Receptor in Patients with Congenital Generalized Lipodystrophy," appears to concern a single unusual metabolic disorder. In fact, this work adds directly to emerging concepts about disorders of insulin sensitivity, including rare ones associated with lipodystrophy or acanthosis nigricans and common ones such as obesity and diabetes1 2 3 4 5 6 (also references cited by Oseid and his colleagues). Moreover, these concepts apply beyond insulin to other hormones and to other regulatory systems that use intercellular humoral signals as diverse in character as neurotransmitters, immunoglobulins and cholesterol-containing serum lipoproteins.6 7 8 9 Recent . . .