CROSS-PROTECTION AGAINST SALMONELLA ENTERITIDIS INFECTION IN MICE .1. IMMUNIZATION TRIALS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (4) , 277-281
Abstract
Mice were immunized s.c. with live and killed vaccines, with and without complete adjuvant incorporating S. typhimurium M206, S. gallinarum 9R, S. pullorum Sp223 and homologous S. enteritidis Se795. The animals were challenged 21 days post-vaccination with 100 LD50 of virulent S. enteritidis 5694 SMR s.c. along with unvaccinated control mice. To assess the immunity against acute and chronic infections, the percentage of absolute survivors, i.e., survivors without lesions and without the challenge organism, was taken as the criterion. Live vaccines proved better than killed vaccines. Live vaccines with complete adjuvant induced a good protection. Cross-protection could be induced with the live vaccine with complete adjuvant against S. enteritidis infection in mice.

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