The Intracellular Target for the Antiresorptive Aminobisphosphonate Drugs in Dictyostelium discoideum Is the Enzyme Farnesyl Diphosphate Synthase
Open Access
- 1 May 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 15 (5) , 971-981
- https://doi.org/10.1359/jbmr.2000.15.5.971
Abstract
Aminobisphosphonate (aBP) drugs inhibit osteoclast-mediated bone resorption and also growth of amoebas of Dictyostelium discoideum apparently by interaction with the same intracellular target. Identi...Keywords
This publication has 25 references indexed in Scilit:
- Differential Effects of Aminosubstituted Analogs of Hydroxy Bisphosphonates on the Growth of Dictyostelium discoideumJournal of Bone and Mineral Research, 1998
- Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino groupJournal of Bone and Mineral Research, 1996
- Structure-activity relationships of four alkylated alendronate derivatives as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium amoebae.Bone, 1995
- Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold dictyostelium discoideumJournal of Bone and Mineral Research, 1994
- Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
- Identification of Cys139 and Glu207 As Catalytically Important Groups in the Active Site of Isopentenyl Diphosphate:Dimethylallyl Diphosphate IsomeraseBiochemistry, 1994
- Isoprenyl diphosphate synthases: Protein sequence comparisons, a phylogenetic tree, and predictions of secondary structureProtein Science, 1994
- A Human Promyelocyte mRNA Transiently Induced by TPA Is Homologous to Yeast IPP IsomeraseGenomics, 1994
- GENE AMPLIFICATIONAnnual Review of Biochemistry, 1984
- Isolation and characterization of a photoaffinity-labeled peptide from the catalytic site of prenyltransferaseBiochemistry, 1981