Pharmacological studies of Panacis Japonici Rhizoma. I.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (5) , 1017-1025
- https://doi.org/10.1248/cpb.25.1017
Abstract
Pharmacological properties of preparations from Panacis Japonici Rhizoma [Panax japonicum] were studied by screening methods. CNS-depressant, tranquilizing, cholinergic, anticholinergic, histamine-like, antihistamine-like, antinicotinic, blood pressure elevating and lowering, and antiinflammatory activities were determined. Chikusetsusaponin III whose aglycone is 20S-protopanaxadiol is especially remarkable for its tranquilizing, anticholinergic, antihistamine-like, antinicotinic, and blood pressure elevating and lowering activities. Cholinergic, histamine-like and blood pressure elevating activities were found in the fraction which did not contain saponins. Antiinflammatory activity was estimated for chikesetsusaponin V. [Mice, rats, rabbits and guinea pigs were used for tests.].This publication has 0 references indexed in Scilit: