Role of Estrogen Receptor in Hematopoietic Stem Cell Development and B Lymphocyte Maturation in the Male Mouse

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Abstract
Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERa in hematopoietic progenitor and B lymphocyte maturation. ERa knock- out (ER2/2), wild-type (ER1/1), and radiation chimeric (ERa positive or negative in either nonhematopoietic or hematopoietic elements, or both) male mice were used to determine target tissues. ER2/2 and ER1/1 animals showed similar hematopoietic progenitor profiles, but the ER2/2 animals had fewer cells in all bone marrow B lymphocyte

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