Monitoring the Disinfection of Honeybee Combs by Ethylene Oxide

Abstract
Brood combs contaminated with larvae killed by American foul brood (scales) were treated with 100 mg per litre of ethylene oxide (ETO) in a vacuum chamber. After exposure for 18 h at 27°C, the scale samples had the same odour, appearance, fluorescence, and proteolytic activity as untreated control scales. Microscopic examination of Bacillus larvae spore suspensions prepared from the scales disclosed no differences in refractility of the spores between treated and untreated samples. Culture of scale suspensions in germination medium revealed no viable spores from the treated group in concentrations as high as 107 spores per tube. However, spores from untreated scales grew in concentrations as low as 101 spores per tube. It is considered that laboratory demonstration of the effectiveness of ETO sterilization can best be made by bacteriological culture.

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