Coexistent Paroxysmal Nocturnal and Cold Hemoglobinuria Preceded by Aplastic Anemia: A Case Report and Family Study

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Abstract
This report described a patient with coexistent paroxysmal cold and nocturnal hemoglobinuria. The hemolytic processes were preceded by a period of marrow aplasia. He demonstrated two complications of prolonged hemolysis and hemoglobinuria, namely iron deficiency and probably "relative folate deficiency." Forty of his family members were investigated for evidence of PNH or PCH and none was found. The need for evaluation and follow up of patients with aplastic anemia in terms of PNH was emphasized.