Escherichia Coli 0127:B8, a Serotype Causing Infantile Diarrhea

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Abstract
Summary: By means of a hemagglutination procedure, the antibody response of premature infants with diarrhea in an epidemic caused by Escherichia coli 0127:B8 was studied. In preliminary experiments with two adult volunteers who had ingested large numbers of these microorganisms, the specificity of the hemagglutinating-antibody was established by the patterns of antibody response and by absorption tests. Hemagglutinating-antibodies were detected in normal adults and transplacental transfer of such antibody was demonstrated. In infected newborn infants, the antibody response was distinguished from transplacental antibody by its pattern of development.