Effects of Pituitary Removal or Transplantation on Ovarian Ascorbic Acid Depletion in the Rat.
- 1 February 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 106 (2) , 362-365
- https://doi.org/10.3181/00379727-106-26339
Abstract
Immature female rats were made pseudopregnant in the manner prescribed for the Parlow LH assay. Hypophysectomy of such animals on the sixth day of pseudopregnancy caused a gradual decline in ovarian weight over a 5-week period but concentration of ovarian ascorbic acid was well maintained. At periods of a week or more after hypophysectomy intravenous injection of LH produced no decline in ovarian ascorbic acid. In other animals the pituitary gland was autografted to the renal capsule on sixth day of pseudopregnancy. Ovarian weight was well maintained in these animals for 4 weeks although at 4 weeks there was a significant decrease in level of ovarian ascorbic acid. Intravenous injection of LH in pituitary graft-bearing rats led to depletion of ovarian ascorbic acid even greater than that found in intact, pseudopregnant rats. It is suggested that animals bearing pituitary autografts should prove valuable in the search for LH releasing factors.Keywords
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