Positive donor and negative recipient cytomegalovirus status is a detrimental factor for long-term renal allograft survival
- 1 December 1994
- journal article
- research article
- Published by Frontiers Media SA in Transplant International
- Vol. 7 (s1) , 336-338
- https://doi.org/10.1111/j.1432-2277.1994.tb01385.x
Abstract
In 524 allogeneic cadaveric kidney transplants, the impact of cytomegalovirus (CMV) donor/recipient status on the incidence of CMV infection, CMV disease, early and long‐term graft, and patient survival have been analyzed with respect to rejection episodes. Most CMV infections (59%) and diseases (17%) were found in CMV‐negative recipients of CMV‐positive kidneys. The 1‐year function rate of CMV‐positive kidneys (75%) dropped about 10% below that of CMV‐negative organs (85%), and in the case of CMV‐negative recipients an additional graft loss of more than 10% happened within the 4th and 5th years (5‐year graft survival pos./neg.: 56%). This detrimental effect was exaggerated if it coincided with antibody‐treated rejection episodes.Keywords
This publication has 3 references indexed in Scilit:
- CYTOMEGALOVIRUS INFECTION—AN ETIOLOGICAL FACTOR FOR REJECTION? A PROSPECTIVE STUDY IN 242 RENAL TRANSPLANT PATIENTSTransplantation, 1993
- CYTOMEGALOVIRUS MATCHING IN RENAL TRANSPLANTATIONThe Lancet, 1988
- MULTICENTER SEROEPIDEMIOLOGIC STUDY OF THE IMPACT OF CYTOMEGALOVIRUS INFECTION ON RENAL TRANSPLANTATIONTransplantation, 1985