Susceptibility of campylobacter species to metronidazole, its bioactive metabolites and tinidazole

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Abstract
Summary The susceptibilities of 115 campylobacters, belonging to five species, to metronidazole, its principal oxidative metabolites and tinidazole were determined by an agar dilution method. The activities of metronidazole and tinidazole were comparable. The hydroxy metabolite was more active than the parent drug against most species, particularlyCampylobacter jejuni andCampylobacter pyloridis. Although the acid derivative was less active againstC. jejuni andCampylobacter coli, it demonstrated an equivalent degree of activity to metronidazole against the remaining species. Inter-species differences existed with respect to the susceptibility of campylobacters and selected nitroimidazole antimicrobials.