The Development of an Oral Controlled Release Pellets Formulation of Diethylpropion Hydrochloride

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Abstract
In the present study, controlled release pellets of the anorexigenic, diethylpropion hydrochloride were formulated. Selected polymeric film coatings were applied to the drug-loaded non pareils and their effect on in vitro drug release from the multiple-units dosage form was examined. It was found that a combination of EudragitR RS, polyethylene glycol 200 and magnesium stearate produced a stable film coat that controlled drug release as desired. Dissolution data demonstrated that this formulation displayed predictable and reproducible drug release characteristics.